At the heart of our MYLBL products is a special sprouted European buckwheat, meticulously selected for its allergen-free profile and remarkable composition rich in bioactive flavonoids, dietary fiber, and exceptionally elevated spermidine content, targeting critical Healthy Aging processes. The buckwheat powder at the heart of our products is sold under the trademark Buckmdine® and is GRAS affirmed. All our products are manufactured in FDA registered facilities.

Autophagy is an essential bodily process involving the degradation and recycling of damaged or obsolete cellular components to maintain cellular health.

As recently as October 2016, Yoshinori Ohsumi was awarded the Nobel Prize in Medicine for his discoveries related to the mechanisms of autophagy.

Autophagy is critical for aging. Think of it in some sense as your body’s internal recycling process, it plays a crucial role in breaking down toxic materials, which is essential for the cell's survival, as a cell lacking autophagy mechanisms cannot survive. Autophagy is an essential cellular process with wide-ranging benefits for the entire body.

The Hallmarks of Aging encompass a set of distinct biological processes and characteristics commonly associated with aging, offering a framework to comprehend and categorize the various pathways through which the root causes of aging contribute to age-related decline and disease. 

The concept being, that if you can slow down those distinct processes you can slow aging and age healthier.

In 2023 a group of leading experts suggested increasing the number of Hallmarks from 9 to 12. These Hallmarks include genomic instability, telomere shortening, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, disabled macroautophagy, chronic inflammation, and dysbiosis.

A limited number of known compounds are believed to alleviate or even reverse the consequences of multiple Hallmarks. Among those are spermidine, flavonoids and fibres.

Spermidine, with a particular emphasis on its capacity to trigger autophagy, has the potential to influence as many as 10 out of the 12 Hallmarks of Aging, while flavonoids, with their antioxidative properties, and dietary fibers may also potentially affect specific hallmarks. When combined, spermidine, flavonoids and dietary fibers - all three nutrients integral components of Buckmidine - have the potential to impact 11 out of the 12 Hallmarks of Aging.

A recent study unveiled the top concerns for Americans when it comes to  Healthy Aging, those are:

1. Cognition / memory health
2. Disease prevention
3. Joint health / inflammation
4. Active lifestyle / fitness

Cognition or memory health

An study done in Austria found that supplementation for 3 months with 3mg/day of spermidine improved cognition (Pekar et al, 2021) . The study was extended to follow the cohort, 45 patients of a nursing home, for 1 year. The results after 1 year show a continuation of the positive effect of oral spermidine intake for patients with neurocognitive impairment (Pekar et al, 2023).

Higher baseline spermidine levels, as revealed in a two-year longitudinal study analyzing 3774 adults, were associated with a lower risk of mild cognitive impairment (Xu et al., 2022).

Disease prevention

Autophagy has been associated with preventing diseases. Spermidine has been observed in epidemiological studies to exhibit cardio- and neuroprotective effects (Hofer et al., 2022).

The U.S. National Health and Nutrition Examination Survey, covering the period from 2003 to 2014, strongly suggests that a higher dietary intake of spermidine is correlated with a decreased risk of cardiovascular disease and all-cause mortality, as highlighted by Wang et al. in 2022.

Joint health / inflammation

Autophagy helps to clean up the cells. Cleaner cells should result in less inflammation. A recent study (Yuan et, 2021) showed that spermidine inhibits joints inflammation and macrophage activation in mice with collagen-induced arthritis. Another publication (Xinjie et al, 2023) focused on spermidine as a therapeutic option for the treatment of OA. However it seems more research is needed into this topic.

The scientific verdict on Flavonoids and chronic inflammation is much clearer (Al-Khayri et al, 2022). Evidence suggests that Flavonoids, such as those found in Buckmidine, have anti-inflammatory effects and also help to improve cellular senescence (Ullah et al, 2020 and Fan et al, 2022).

Active lifestyle / fitness performance

Can spermidine, flavonoids and fibers help you to live a more active lifestyle?

Nutrients cannot live your life for you, however nutrition and nutrients impact physical and mental well-being. Certainly some nutrients support you to live a more active life.

As you age spermidine levels in your body decrease. Studies have shown that spermidine-rich diets are associated with significant health benefits, such as mental and cardiovascular health. Does that mean you will not age or not get ill if you take our products? No, of course it doesn’t.

Our products are intended to elevate the spermidine intake of your daily diet.

The above is a summary of recent scientific publications, please see below a list of some of those. Are you interested to read more about spermidine, flavonoids, buckwheat and aging?

Please see a selected list of scientific literature:

Chettry U, Chrungoo NK. Beyond the Cereal Box: Breeding Buckwheat as a Strategic Crop for Human Nutrition. Plant Foods Hum Nutr. 2021 Dec;76(4):399-409. doi: 10.1007/s11130-021-00930-7. Epub 2021 Oct 15. PMID: 34652552.

Stefan Kiechl, Johann Willeit; In a Nutshell: Findings from the Bruneck Study. Gerontology 16 January 2019; 65 (1): 9–19. https://doi.org/10.1159/000492329

Hofer, S.J., Simon, A.K., Bergmann, M. et al. Mechanisms of spermidine-induced autophagy and geroprotection. Nat Aging 2, 1112–1129 (2022). https://doi.org/10.1038/s43587-022-00322-9

Pekar, T., Bruckner, K., Pauschenwein-Frantsich, S. et al. The positive effect of spermidine in older adults suffering from dementia. Wien Klin Wochenschr 133, 484–491 (2021). https://doi.org/10.1007/s00508-020-01758-y

Pekar, T., Wendzel, A. & Jarisch, R. The positive effect of spermidine in older adults suffering from dementia after 1 year. Wien Klin Wochenschr 136, 64–66 (2024). https://doi.org/10.1007/s00508-023-02226-z

Wang Z, Han T, Sun C, Wei W, Jiang W. The association of dietary spermidine with all-cause mortality and CVD mortality: The U.S. National Health and Nutrition Examination Survey, 2003 to 2014. Front Public Health. 2022 Sep 28. https://doi.org/10.3389/fpubh.2022.949170

Xinjie Mao, Bing Yan, Hongjie Chen, Peng Lai, Jinzhong Ma, BRG1 mediates protective ability of spermidine to ameliorate osteoarthritic cartilage by Nrf2/KEAP1 and STAT3 signaling pathway, International Immunopharmacology,Volume 122, 2023. https://doi.org/10.1016/j.intimp.2023.110593.

Xu J, Sun Z, Zhang R, Li R, Yu Z, Zhang Q, Ma Y, Xing F, Zheng L. Non-linear association between serum spermidine and mild cognitive impairment: Results from a cross-sectional and longitudinal study. Front Aging Neurosci. 2022 Aug 2;14:924984. doi: 10.3389/fnagi.2022.924984. PMID: 35983378; PMCID: PMC9380894.

López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: An expanding universe. Cell. 2023 Jan 19;186(2):243-278. doi: 10.1016/j.cell.2022.11.001. Epub 2023 Jan 3. PMID: 36599349.

Ullah A, Munir S, Badshah SL, Khan N, Ghani L, Poulson BG, Emwas AH, Jaremko M. Important Flavonoids and Their Role as a Therapeutic Agent. Molecules. 2020 Nov 11;25(22):5243. doi: 10.3390/molecules25225243. PMID: 33187049; PMCID: PMC7697716.

Al-Khayri JM, Sahana GR, Nagella P, Joseph BV, Alessa FM, Al-Mssallem MQ. Flavonoids as Potential Anti-Inflammatory Molecules: A Review. Molecules. 2022 May 2;27(9):2901. doi: 10.3390/molecules27092901. PMID: 35566252; PMCID: PMC9100260.

Fan X, Fan Z, Yang Z, Huang T, Tong Y, Yang D, Mao X, Yang M. Flavonoids—Natural Gifts to Promote Health and Longevity. International Journal of Molecular Sciences. 2022; 23(4):2176. https://doi.org/10.3390/ijms23042176